The Need for Pediatric Formulations to Treat Children with HIV
نویسندگان
چکیده
Over 3.2 million children worldwide are infected with HIV, but only 24% of these children receive antiretroviral therapy (ART). ART adherence among children is a crucial part of managing human-immunodeficiency virus (HIV) infection and extending the life and health of infected children. Important causes of poor adherence are formulation- and regimen-specific properties, including poor palatability, large pill burden, short dosing intervals, and the complex storage and transportation of drugs. This review aims to summarize the various regimen- and formulation-based barriers to ART adherence among children to support the need for new and innovative pediatric formulations for antiretroviral therapy (ART). Detailing the arguments both for and against investing in the development of pediatric HIV medications, as well as highlighting recent advances in pediatric ART formulation research, provides a synopsis of the current data related to pediatric ART formulations and adherence.
منابع مشابه
Increasing antiretroviral drug access for children with HIV infection.
Although there have been great gains in the prevention of pediatric HIV infection and provision of antiretroviral therapy for children with HIV infection in resource-rich countries, many barriers remain to scaling up HIV prevention and treatment for children in resource-limited areas of the world. Appropriate testing technologies need to be made more widely available to identify HIV infection i...
متن کاملThe Diagnosis of HIV Infection in Infants and Children
It is estimated that the number of HIV infected children globally has increased from 1.6 million in 2001 to 3.3 million in 2012. The number of children below 15 years of age living with HIV has increased worldwide. Published data from recent studies confirmed dramatic survival benefit for infants started anti-retroviral therapy (ART) as early as possible after diagnosis of HI. Early confirmatio...
متن کاملThe global pediatric antiretroviral market: analyses of product availability and utilization reveal challenges for development of pediatric formulations and HIV/AIDS treatment in children
BACKGROUND Important advances in the development and production of quality-certified pediatric antiretroviral (ARV) formulations have recently been made despite significant market disincentives for manufacturers. This progress resulted from lobbying and innovative interventions from HIV/AIDS activists, civil society organizations, and international organizations. Research on uptake and dispersi...
متن کاملO-13: Reproductive Health Options among HIV-Infected Persons in The Low Income Niger Delta of Nigeria
Background: With the advent and wide spread use of Highly Active Antiretroviral Therapy (HAART) for the treatment of HIV, persons living with HIV/AIDS are living a good quality, longer and healthier lives. Many HIVaffected couples (sero-discordant and sero-concordant) are beginning to consider options for safer reproduction. The aim of this study was to assess the reproductive health concerns a...
متن کاملIntestinal Pseudo-Obstruction as an Unusual Gastrointestinal Presentation in Pediatric Human Immunodeficiency Virus Infection
Intestinal pseudo-obstruction is a condition in which the intestine’s ability to push food through is reduced. It often leads to the dilation of the various parts of the bowel. It can be idiopathic or inherited from a parent, or caused by another disease. We report a rare case of human immunodeficiency virus (HIV) infection in a 3-year-old boy who referred with acute abdominal pain, and was lat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2016 شماره
صفحات -
تاریخ انتشار 2016